| Description | Cholestyramine (Cholestyramine resin), a bile acid-binding resin, inhibits intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol. |
| In vivo | GSPE单独治疗以及与胆酸结合树脂(Cholestyramine)联合应用，与单独使用胆酸结合树脂相比，对BA、胆固醇和TG的代谢产生不同的调节作用。值得注意的是，GSPE能降低肠道顶膜钠依赖性胆酸转运蛋白(Asbt)基因的表达，而胆酸结合树脂显著诱导该基因表达。无论是GSPE还是胆酸结合树脂的使用，均能显著诱导肝脏BA生物合成基因的表达。与对照组相比胆固醇7α-羟化酶(Cyp7a1)表达更为增强，而联合应用可以进一步促进表达。胆酸结合树脂治疗诱导肠道和肝脏胆固醇生成基因的表达，而与GSPE联合应用则减弱了胆酸结合树脂在肝脏引起的表达增加，但肠道不受影响。胆酸结合树脂还诱导肝脏脂肪生成基因的表达，这一作用也可通过与GSPE联合应用得到减缓[2]。 |
| Synonyms | Colestyramine, 考来烯胺, Cholestyramine resin |
| molecular weight | 435.14 |
| Molecular formula | C27H47ClN2 |
| CAS | 11041-12-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: < 0.1 mg/mL (insoluble) DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Maugeais C, et al. rHDL administration increases reverse cholesterol transport in mice, but is not additive on top of ezetimibe or cholestyramine treatment. Atherosclerosis. 2013 Jul;229(1):94-101. 2. Rebecca M. Heidker, et al. Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver. PLoS One. 2016; 11(4): e0154305. |