| Description | Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. |
| In vitro | Acetoacetic acid sodium salt 通过诱导氧化应激抑制牛肝细胞中极低密度脂蛋白(VLDL)的组装。Acetoacetic acid sodium salt （0.6、2.4、4.8 mM）在高剂量组 (GH) 中增加丙二醛(MDA)含量，降低所有组中锰超氧化物歧化酶(Mn-SOD)、铜锌超氧化物歧化酶(Cu/Zn SOD)和谷胱甘肽过氧化物酶(GSH-Px)的mRNA表达水平，并在中剂量组 (GM) 和GH组减少过氧化氢酶(CAT)的mRNA表达。此外，Acetoacetic acid sodium salt 下调载脂蛋白B100 (ApoB100)、载脂蛋白E (ApoE) 及低密度脂蛋白受体 (LDLR) 的mRNA表达。因此，在这些牛肝细胞中VLDL组装减少，三酸甘油酯(TG)积累增加。 |
| Synonyms | 乙酰乙酸钠, 3-氧代丁酸钠盐 |
| molecular weight | 124.07 |
| Molecular formula | C4H5NaO3 |
| CAS | 623-58-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 50 mg/mL (403.00 mM), Sonication is recommended. |
| References | 1. Shi X, et al. Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. J Dairy Res. 2016 Nov;83(4):442-446. |