| Description | Chlormequat chloride (EI 38,555), a plant growth regulator, is widely applied in agriculture because it can promote sturdier growth of the crops. |
| In vitro | Chlormequat chloride在150μg/ml (0.93mM)浓度下延缓了大鼠胚胎的生长，但没有引起显著的形态畸形；在500μg/ml (3.1mM)浓度时，不仅延缓了胚胎生长，还引起了形态畸形。然而，即便在高达1000μg/ml (6.2mM)的浓度下，chlormequat chloride亦未影响肢芽细胞的增殖和分化。通过3T3成纤维细胞的毒性测试，此浓度下的chlormequat chloride同样未对细胞活性产生影响，这表明细胞毒性可能并非chlormequat chloride抑制大鼠胚胎生长的作用机理[1]。 |
| In vivo | Chlormequat chloride（5 μg/mL）相比对照组，在体内外均能提高胚胎生长激素（GH）和胰岛素样生长因子1（IGF-1）的水平[1]。 |
| Synonyms | NSC 34858, NSC34858, EI 38,555, NSC-34858, EI-38,555, 矮壮素, EI38,555 |
| molecular weight | 158.07 |
| Molecular formula | C5H13Cl2N |
| CAS | 999-81-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/ml (411.21 mM) |
| References | 1. Xiagedeer B, et al. Chlormequat chloride retards rat embryo growth in vitro. Toxicol In Vitro. 2016 Aug;34:274-82. 2. Zhou X, et al. [Simultaneous determination of chlormequat chloride and mepiquat chloride in plants by mobile phase ion chromatography]. Se Pu. 2011 Mar;29(3):244-8. Chinese 3. Huang D, et al. The effects of chlormequat chloride on the development of pubertal male rats. Environ Toxicol Pharmacol. 2016 Oct;47:92-99. 4. Xiagedeer B, et al. Chlormequat chloride promotes rat embryonic growth and GH-IGF-1 axis. Toxicology. 2020 Jan 15;429:152326. |