| Description | Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM). |
| In vitro | Chlorantraniliprole有效且选择性地激活昆虫的ryanodine受体，通过ryanodine受体介导的内部Ca2+储存释放发挥作用。相比于果蝇(Drosophila melanogaster)和H. virescens中的昆虫RyRs（EC50分别为40 nM、50 nM），Chlorantraniliprole对小鼠肌母细胞系C2C12中的ryanodine受体(RyRs)的潜力约低300倍（EC50为14 μM），并且在大鼠细胞系RyR2中几乎没有选择性（EC50大于100 μM）[1]。 |
| In vivo | Chlorantraniliprole在大鼠中的急性口服LD50值大于5000 mg/kg，表现出低急性哺乳动物毒性，并在高达1500 mg/kg/日的剂量下，在90天的研究中几乎没有或没有毒性[1]。 |
| Synonyms | Rynaxypyr, Chlorantranilipole, Rynaxpyr |
| molecular weight | 483.15 |
| Molecular formula | C18H14BrCl2N5O2 |
| CAS | 500008-45-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 56.7 mg/mL (117.4 mM) |
| References | 1. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279. |
| Citations | 1. Li B J, Wang K K, Yu Y, et al.PxRdl2 dsRNA increased the insecticidal activities of GABAR-targeting compounds against Plutella xylostella.Pesticide Biochemistry and Physiology.2023: 105548. |