| Description | CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes. |
| In vivo | CGP71683（1-10 mg/kg，i.p.）按剂量依赖性降低了夜间和禁食诱导的食物摄入量。在大鼠社会互动测试中，CGP71683A没有表现出类似焦虑的效果。在紧接着高架十字迷宫测试进行的开放场测试中，CGP71683A抑制了水平和垂直活动[2]。 |
| Target activity | Y1 receptor:>4000 nM (Ki), Y5 receptor:1.3 nM (Ki), Y2 receptor:200 nM (Ki) |
| Synonyms | CGP71683A, 盐酸CGP71683 |
| molecular weight | 512.07 |
| Molecular formula | C26H30ClN5O2S |
| CAS | 192322-50-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 120 mg/mL (234.34 mM) H2O: 10 mg/mL (19.53 mM) |
| References | 1. Lecklin A, et al. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37. 2. Kask A, et al. Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur J Pharmacol. 2001 Mar 2;414(2-3):215-24. |