| Description | AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced nociceptive sensitization, and may be used to study neurological.... |
| In vivo | NPFF2 激动剂 AC-099 ( 30 mg/kg; i.p.) 在体内各种疼痛模型中具有活性，而非选择性 NPFF1 激动剂给药会增加对有害和非有害刺激的敏感性[1]。 |
| molecular weight | 301.1 |
| Molecular formula | C9H9Cl2F3N4 |
| CAS | 849335-07-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. 2. Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. |