| Description | Cetaben is a PPARα-independent peroxisome proliferator. Cetaben is a non-fibrotic lipid-lowering drug that effectively reduces cholesterol and triglyceride concentrations. |
| In vitro | 将10 μM Cetaben作用于HepG2和MH1C1细胞24小时后，引发了显著的微观形态学和超微结构变化。Cetaben处理 24 小时后，MH1C1细胞的过氧化物酶体群展现出显著的异质性，出现哑铃形和杯状的过氧化物酶体轮廓。而100 μM Cetaben处理则导致细胞中含有数个高尔基体区域，其中大部分解离成小泡[2]。 |
| In vivo | 给予50-100 mg/kg 的Cetaben超过10天，可明显增加肝脏和肾脏中过氧化物酶的活性。然而，最大效应观察于250 mg/kg[1]。 |
| molecular weight | 361.56 |
| Molecular formula | C23H39NO2 |
| CAS | 55986-43-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: ＜1 mg/mL (insoluble or slightly soluble) |
| References | 1. Chandoga J, et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochem Pharmacol. 1994 Feb 9;47(3):515-9. 2. Kovacs W, et al. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatomacells and HepG2 human hepatoblastoma cells. Histochem Cell Biol. 2001 Jun;115(6):509-19. |