| Description | CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis. |
| In vitro | CCX354 displays potent activities in the chemotaxis assay (IC50<100 nM).[1] |
| In vivo | CCX354 has in vivo anti-inflammatory activity. It also has superior pharmacokinetic properties.[1] |
| Synonyms | CCR1 antagonist 1, CCX-354, CCX 354 |
| molecular weight | 451.91 |
| Molecular formula | C22H22ClN7O2 |
| CAS | 1010073-75-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (132.77 mM) |
| References | 1. Daniel Dairaghi, et al. Compounds for the treatment of osteoporosis and cancers. US20100113472 A1. |