| Description | CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor 1 is useful for in vitro and in vivo pathophysiology studies as a small molecule inhibitor of CCR6. |
| In vitro | 在人类CCR6转染的CHO细胞中，CCR6 inhibitor 1 显示出Gi信号抑制活性与细胞迁移抑制活性之间良好的相关性，能够有效抑制依赖CCR6的细胞迁移以及人类初代细胞中ERK磷酸化的增加[1]。 |
| Target activity | CCR6 (monkey):0.45 nM, CCR7 (human):9400 nM, CCR6 (human):6 nM |
| molecular weight | 504.52 |
| Molecular formula | C24H23F3N4O3S |
| CAS | 2437547-04-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 112.5 mg/mL (223.0 mM) |
| References | 1. Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072. |