| Description | Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galactosamine injury and has potential anti-Alzheimer's disease (AD) activity. |
| Target activity | BACE1:4.45 μM, BACE1:9.85 μM(Ki) |
| molecular weight | 420.37 |
| Molecular formula | C20H20O10 |
| CAS | 13709-03-0 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 20 mg/mL (47.57 mM), Sonication is recommended. |
| References | 1. Choi JS, et al. In vitro antimutagenic effects of anthraquinone aglycones and naphthopyrone glycosides from Cassia tora. Planta Med. 1997;63(1):11-14. 2. Jung HA, et al. Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases. J Ethnopharmacol. 2016;191:152-160. 3. Choi JS, et al. Alaternin, cassiaside and rubrofusarin gentiobioside, radical scavenging principles from the seeds of Cassia tora on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Arch Pharm Res. 1994;17(6):462-466. |