| Description | β-Amyloid (1-42), human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. |
| In vitro | Amyloid β-Peptide (1-42) human是一种42氨基酸肽，对阿尔茨海默病的发生发展起着关键作用。在浴液中使用1到10μM浓度的Amyloid β-Peptide (1-42) human不会影响延迟整流K+电流和泄漏电流，但会增强Ca2+电流的失活并阻断Ca2+-依赖的K+电流[1]。在2.5μM浓度下，Amyloid β-Peptide (1-42) human使SH-SY5Y细胞的存活率降低至65%。研究表明，经过30分钟的孵育后，Amyloid β-Peptide (1-42) human在SH-SY5Y细胞的细胞质和核内均有定位，而在8小时后，会在细胞质和核内看到Amyloid β-Peptide (1-42) human的大量积累。经Amyloid β-Peptide (1-42) human处理后，还检测到APP mRNA水平的增加[2]。 |
| Synonyms | 大豆肽, β-Amyloid (1-42), human, Amyloid β-Peptide (1-42) human |
| molecular weight | 4514.04 |
| Molecular formula | C203H311N55O60S |
| CAS | 107761-42-2 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (11.08 mM), Sonication is recommended. |
| References | 1. Solntseva EI, et al. Impact of amyloid-β peptide (1-42) on voltage-gated ion currents in molluscan neurons. Bull Exp Biol Med. 2011 Oct;151(6):671-4. |
| Citations | 1. Deng J L, Huang L F, Bian Z Y, et al.A new neuroprotective candidate TJ1 targeting amyloidogenesis in 5xFAD Alzheimer’s disease mice.International Immunopharmacology.2024, 138: 112653. |