| Description | Carbidine (Carbidin) is a derivative of gamma-carboline, an atypical antipsychotic drug. It reduces the inhibitory effect of DA on the 3H-DA release from synaptosomes of the nucleus accumbens septi and on the activity of tyrosine hydroxylase in vivo and in vitro. |
| In vivo | 在施用Carbidine（5 mg/kg, i.p.）后，发现Carbidine的最大IFC约为1 mu M，在注射后20-40分钟达到峰值。Carbidine（1 mu M, i.p.）可提高多巴胺释放量，但对其代谢物透析液水平的影响不足。此外，Carbidine（0.2及0.5 mg/kg, i.p.）能刺激未经手术的大鼠的运动活动[1]。 |
| Synonyms | Dicarbine dihydrochloride, Karbidin, Carbidin, Karbidine |
| molecular weight | 275.217 |
| Molecular formula | C13H20Cl2N2 |
| CAS | 33162-17-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 2.75 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Proskuriakova TV, Gurtovenko VM, Gorshkova EP. [Comparative evaluation of the effect of carbidine and levamisole on the E-rosette-forming activity of the lymphocytes in alcoholic intoxication]. Farmakol Toksikol. 1989 Jan-Feb;52(1):94-8. Russian. 2. Kudrin VS, et al. [Effect of the atypical neuroleptics carbidine and sulpiride on dopamine biosynthesis in the synaptosomes of the nucleus accumbens septi in rats]. Farmakol Toksikol. 1987 Mar-Apr;50(2):16-20. Russian. 3. Zharkovskiĭ AM, Klassen NE, Zharkovskiĭ TA. [Effect of carbidine on the dopamine and serotonin receptors of the central nervous system]. Biull Eksp Biol Med. 1985 Jun;99(6):700-2. Russian. 4. Gainetdinov RR, et al. Simultaneous monitoring of dopamine, its metabolites and trans-isomer of atypical neuroleptic drug carbidine concentrations in striatal dialysates of conscious rats. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Feb;20(2):291-305. |