| Description | Captopril disulfide, a metabolite of Captopril, is a new antihypertensive agent. |
| Synonyms | SQ14,551, SQ 14,551, SQ-14,551 |
| molecular weight | 432.56 |
| Molecular formula | C18H28N2O6S2 |
| CAS | 64806-05-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Bojarska J, Maniukiewicz W, Fruziński A, Sieroń L, Remko M. Captopril and its dimer captopril disulfide: comparative structural and conformational studies. Acta Crystallogr C Struct Chem. 2015 Mar;71(Pt 3):199-203. doi: 10.1107/S2053229615002582. Epub 2015 Feb 18. PubMed PMID: 25734850. 2. Mahmoud WM, Kümmerer K. Captopril and its dimer captopril disulfide: photodegradation, aerobic biodegradation and identification of transformation products by HPLC-UV and LC-ion trap-MS(n). Chemosphere. 2012 Aug;88(10):1170-7. doi: 10.1016/j.chemosphere.2012.03.064. Epub 2012 Apr 24. PubMed PMID: 22534199. 3. Drummer OH, Jarrott B. Captopril disulfide conjugates may act as prodrugs: disposition of the disulfide dimer of captopril in the rat. Biochem Pharmacol. 1984 Nov 15;33(22):3567-71. PubMed PMID: 6095854. 4. Bathala MS, Weinstein SH, Meeker FS Jr, Singhvi SM, Migdalof BH. Quantitative determination of captopril in blood and captopril and its disulfide metabolites in plasma by gas chromatography. J Pharm Sci. 1984 Mar;73(3):340-4. PubMed PMID: 6371216. |