| Description | Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce ROS production. |
| In vitro | Camalexin 对人类乳腺癌细胞系表现出抗增殖活性。对于卵菌门真菌Phytophthora和Pythium，Nep1-like蛋白是Camalexin合成和活性氧（ROS）形成的初始诱导因素。活性氧被普遍认为与Camalexin形成密切相关。在筛选对Alternaria brassicicola敏感性增强的过程中，识别出esa1突变体，该突变体显示出Camalexin诱导的延迟。在响应诱导ROS的试剂时，合成了减少的Camalexin水平。ESA1的关键作用通过esa1突变体在响应Leptosphaeria maculans时无法合成Camalexin的事实得到了确认[2]。 |
| molecular weight | 200.26 |
| Molecular formula | C11H8N2S |
| CAS | 135531-86-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 120 mg/mL (599.22 mM), Sonication is recommended. |
| References | 1. William A.Ayer, et al. Synthesis of camalexin and related phytoalexins. Tetrahedron. Volume 48, Issue 14, 1992, Pages 2919-2924. 2. Glawischnig E. Camalexin. Phytochemistry. 2007 Feb;68(4):401-6. 3. Mezencev R, et al. Antiproliferative and cancer chemopreventive activity of phytoalexins: focus on indole phytoalexins from crucifers. Neoplasma. 2003;50(4):239-45. |