| Description | Butylphthalide (3-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of Apium graveolens Linn. |
| In vivo | Butylphthalide因應慢性腦缺血所引起的氧化应激，改善胆碱能功能，并抑制淀粉样β蛋白的积累，从而改善脑神经损伤和认知缺陷[1]。通过给4月龄的SAMP8小鼠连续口服NBP 2个月，显著提高了空间学习和记忆能力。此外，SAMP8小鼠中脑内侧隔核及斜纹体垂直肢的胆碱乙酰转移酶(ChAT)阳性神经元的损失速度减缓，海马区、大脑皮层和前脑中ChAT的蛋白质及mRNA表达的下降也得到了减缓[2]。 |
| Synonyms | 丁基苯酞, 3-Butylphthalide, 3-n-Butylphathlide, 3-n-Butylphthalide |
| molecular weight | 190.24 |
| Molecular formula | C12H14O2 |
| CAS | 6066-49-5 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (236.54 mM) |
| References | 1. Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26. 2. Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36(3):224-33. |