| Description | Bremelanotide Acetate (PT-141 Acetate) is an agonist of melanocortin receptor (MCR) . |
| In vivo | 在双层实验室中，对经E+P或E独立预处理的雌性动物，使用Bremelanotide（剂量为100或200 μg/kg）显著增加了求偶引诱行为[1]。 |
| Animal experiments | Bremelanotide(PT-141), a cyclic heptapeptide melanocortin analogue (Palatin Technologies, Cranbury, NJ), was dissolved in saline to obtain doses of 50, 100, and 200 μg/kg/ml, and injected s.c. 5 min before each behavioral test. An equal volume of saline was administered to control animals[1]. |
| Synonyms | bremelanotide, PT-141 Acetate |
| molecular weight | 1085.22 |
| Molecular formula | C52H72N14O12 |
| CAS | 1607799-13-2 |
| Storage | keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 36 mg/mL (33.17 mM) |
| References | 1. Pfaus JG, Shadiack A, Van Soest T,et al.Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist[J].Proc Natl Acad Sci U S A. 2004 Jul 6;101(27) 2. Clayton AH, Althof SE, Kingsberg S,et al.Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial[J].Womens Health (Lond). 2016 Jun;12(3):325-37. |