| Description | BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274. It impairs the anchorage-independent growth of KEAP1-mutant cancer cells. |
| In vitro | BPK-29在KEAP1突变的非小细胞肺癌[1]中，显著地且具有良好蛋白质组选择性地作用于NR0B1。 |
| molecular weight | 506.46 |
| Molecular formula | C26H33Cl2N3O3 |
| CAS | 2444815-73-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 62.5 mg/mL (123.41 mM), Sonication is recommended. |
| References | 1. Bar-Peled L, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19;171(3):696-709.e23. |