| Description | BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator. |
| In vitro | BMS-191095 在去内皮的脑动脉中引发剂量依赖性的血管舒张，对应 10, 50 和 100 μM 时分别产生 8.1 ± 2.3%、31.6 ± 2.1% 和 39.5 ± 3.2% 的血管松弛。BMS-191095 还能诱导线粒体去极化和血管舒张。 |
| In vivo | 在正常大鼠中，BMS-191095引起的血管舒张是通过线粒体去极化和VSM中钙火花的产生介导的，且通过抑制BKCa通道减弱其血管扩张活性。 |
| molecular weight | 408.88 |
| Molecular formula | C22H21ClN4O2 |
| CAS | 166095-21-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90 mg/mL (220.11 mM) |
| References | 1. Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503. |