| Description | BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor). |
| In vivo | BIBO3304 TFA（15-60 μg）具有剂量依赖性地抑制由1 μg NPY介导的摄食反应。BIBO3304 TFA（30 μg；双侧室旁核注射）减弱了禁食后的暴食现象[1]。BIBO3304 TFA（0.5 μM；口服）显著提高血清胰岛素水平[2]。 |
| Target activity | NPYY1 receptor:0.38 nM(human), NPYY1 receptor:0.72 nM (rat) |
| molecular weight | 643.66 |
| Molecular formula | C31H36F3N7O5 |
| CAS | 191868-14-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (155.36 mM), Sonication is recommended. |
| References | 1. Wieland HA, et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br J Pharmacol. 1998 Oct;125(3):549-55. 2. Loh K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8(1):490. |