| Description | BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865. |
| In vitro | 通过转染不同的突变 KRAS 癌基因（例如 KRAS G12C、KRAS G12D、KRAS G12V）而依赖 KRAS 的 Ba/F3 细胞系中，BI-2493 抑制增殖，IC50 值 < 140 nM [1]。 |
| In vivo | BI-2493（90mg/kg；灌胃）可减弱携带 KRAS G12C、G12D、G12V 和 A146V 突变模型的小鼠的肿瘤生长，且不会对小鼠造成明显的毒性[1]。 |
| molecular weight | 461.58 |
| Molecular formula | C24H27N7OS |
| CAS | 2937344-16-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (129.99 mM), Sonication and heating are recommended. |
| References | 1. Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023 Jul;619(7968):160-166. |