| Description | 1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a significant decrease in the severity of liver fibrosis and the absence of cirrhotic transformation of the liver. 2. Betulonic acid derivatives have a promising cytostatic activity in vitro and could be used as potential leads for the development of new type of anti-cancer agents. 3. Betulonic acid has antiholestatic effects in mice. |
| Synonyms | 路路通酸, (+)-Betulonic acid, Betunolic acid, Liquidambaric acid |
| molecular weight | 454.68 |
| Molecular formula | C30H46O3 |
| CAS | 4481-62-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.55 mg/mL (10 mM) |
| References | 1. Pavlova N I , Savinova O V , Nikolaeva S N , et al. Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses[J]. Fitoterapia, 2003, 74(5):489-492. |
| Citations | 1. Jung D H, Lee A, Hwang Y H, et al.Therapeutic effects of Pulsatilla koreana Nakai extract on ovalbumin-induced allergic rhinitis by inhibition of Th2 cell activation and differentiation via the IL-4/STAT6/GATA3 pathway.Biomedicine & Pharmacotherapy.2023, 162: 114730. |