| Description | BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM). |
| In vitro | BACE1-IN-2 (Compound 3) is 10-fold more potent toward BACE1 than BACE2, inhibition of which may lead to hair depigmentation. BACE1-IN-2 inhibits hAβ42 cells (IC50: 6.0 nM). |
| Target activity | BACE1:22 nM |
| molecular weight | 421.35 |
| Molecular formula | C19H15F4N5O2 |
| CAS | 1352416-78-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61(12):5292-5303. |