| Description | ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM. |
| Target activity | KRas (G12C):40 nM (IC50) |
| molecular weight | 747.85 |
| Molecular formula | C40H48F3N7O4 |
| CAS | 2241719-73-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 250 mg/mL (334.29 mM), Sonication is recommended. |
| References | 1. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18. |