| Description | Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD. |
| In vitro | Apostatin-1抑制了由bortezomib引起的凋亡以及依赖ripk1的凋亡(RDA)，其半抑制浓度(IC50)约为1μM。 |
| Synonyms | Apt-1 |
| molecular weight | 345.5 |
| Molecular formula | C19H27N3OS |
| CAS | 2559703-06-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 9 mg/mL (26.06 mM), Sonication is recommended. DMSO: 50 mg/mL (144.72 mM), Sonication is recommended. |
| References | 1. Xu D , Zhao H , Jin M , et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis[J]. Nature, 2020, 587(7832):1-6. |