| Description | Compound B14 (Antibacterial agent 141) exhibits antibacterial activity against the plant pathogens Xoo, Xac, Psa, and Cmm, with an EC50 value of 1.28 μM. It functions by inhibiting cell membrane formation and altering cell permeability. |
| In vitro | Antibacterial agent 141 明显促进Xoo细菌细胞膜破裂，并以剂量依赖性的方式提高细菌膜的透性。该化合物破坏Xoo细菌的膜表面结构，并在浓度为3.2和6.4 μM时显著降低ACC、ACP和Fab家族基因的表达，有效抑制Xoo生物膜的形成。同时，Antibacterial agent 141在0.64-5.12 μM范围内，经过3至30小时处理，能显著阻断Xoo细菌的生长，但其对HepG2和HK-2细胞的毒性较低。 |
| In vivo | 抗菌剂141（200 μg/mL；7天；单剂量）在抑制白叶枯病方面，治疗活性为4.64%，保护活性为43.33%[1]。 |
| molecular weight | 414.93 |
| Molecular formula | C23H27ClN2O3 |
| CAS | 2930013-56-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |