| Description | Antibacterial agent 140 chloride, a first-of-its-kind Ru-based AIEgen photosensitizer, shows promise in detecting and treating Gram-positive bacteria (G+). It effectively discriminates against and exterminates G+ by interacting with lipoteichoic acids (LTA), displaying robust antibacterial activity under light irradiation [1]. |
| In vitro | 抗菌剂140氯化物（0.1-5 μg/mL，1h）在暗处呈现出78%-0%的剂量依赖性杀菌效果，暗示在未光照条件下Ru2对S. aureus具备一定的抑制能力。抗菌剂140氯化物在120秒光照下，显著地显示出剂量和时间依赖性，Ru2在低剂量光照下能够有效抑制金黄色葡萄球菌的增长。此外，抗菌剂140氯化物与HeLa细胞共孵育时，80%以上的HeLa细胞存活，并且在小于或等于32μM的光照条件下，有超过73%的HeLa细胞存活。 |
| In vivo | 抗菌剂140氯化物（20 μg/mL/50 μL；1-10天）显著缩小了金黄色葡萄球菌感染所致的伤口，雌性昆明小鼠的伤口在7天内几乎完全愈合。 |
| molecular weight | 1162.1 |
| Molecular formula | C61H44Cl2N8Ru2- |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |