| Description | AChE-IN-29, a 3-OH pyrrolidine derivative, acts as a cholinesterase (ChE) inhibitor with potent activity against human acetylcholinesterase (hAChE), electric eel acetylcholinesterase (eeAChE), and equine butyrylcholinesterase (eqBChE), exhibiting IC50 values of 0.25 μM, 0.23 μM, and 0.72 μM, respectively. It is utilized in Alzheimer's disease research [1]. |
| In vitro | AChE-IN-29（VA10）能有效抑制AChE、BChE以及Aβ1-42。其对hAChE、eeAChE和eqBChE展现出的胆碱酯酶抑制活性，具有IC 50值分别为0.25 μM、0.23 μM和0.72 μM。同时，AChE-IN-29在DPPH实验中表现出显著的抗氧化活性，IC 50值达到24.12 μM。此外，AChE-IN-29在5 μM、10 μM、20 μM剂量下能够抑制自身及hAChE诱导的Aβ1-42的聚集。 |
| In vivo | AChE-IN-29（VA10）（p.o.；2.5、5及10 mg/kg）能够通过抑制AChE活性从而有效改善记忆与认知障碍[1]。此外，AChE-IN-29（p.o.；10 mg/kg）还能恢复海马区域的细胞密度[1]。 |
| molecular weight | 375.26 |
| Molecular formula | C18H19BrN2O2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |