| Description | AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. |
| In vitro | AMN082 抑制了 4-aminopyridine 引起的谷氨酸释放，而这一现象被代谢型谷氨酸 mGlu7 受体拮抗剂 MMPIP 所阻断。此外，西方印迹分析和免疫细胞化学证实了突触前代谢型谷氨酸 mGlu7 受体蛋白的存在。通过螯合细胞外 Ca2+ 离子和囊泡转运体抑制剂，AMN082 对 4-aminopyridine 引起的谷氨酸释放的影响被阻止。[1] |
| In vivo | 动物预先处理较低剂量的AMN082（1.25-5.0 mg/kg，腹腔注射），在每次可卡因或吗啡注射前30分钟，或在重复给药期间及可卡因或吗啡挑战前，能剂量依赖性地减弱可卡因或吗啡引起的运动敏感化的发展和表达。[2] |
| Synonyms | AMN 082 dihydrochloride |
| molecular weight | 465.46 |
| Molecular formula | C28H30Cl2N2 |
| CAS | 97075-46-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wang CC, et al. Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal. Eur J Pharmacol. 2018;823:11-18. 2. Jenda M, et al. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015;57:166-175. |