| Description | AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines. |
| In vitro | AHR antagonist 5 free base induces an activated human T cell state and inhibits CYP1A1 and interleukin (IL)-22 gene expression. AHR antagonist 5 increases pro-inflammatory cytokines, such as IL-2 and IL-9[1]. |
| molecular weight | 441.5 |
| Molecular formula | C25H24FN7 |
| CAS | 2247950-42-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (113.25 mM) |
| References | 1. Marta Sanchez-Martin, et al. Ahr inhibitors and uses thereof. WO2021142180A1. |