| Description | ADT-007 is an orally active and selective pan-RAS inhibitor with potent anticancer activity.ADT-007 blocks GTP activation of RAS and MAPK/AKT signaling by binding to anucleotide RAS.ADT-007 is used in the study of gastrointestinal cancers. |
| In vivo | 在注射了结直肠癌细胞的 6-8 周龄 BALB/C 小鼠中，ADT-007（10 mg/kg；肿瘤内注射；每天一次；持续 17-21 天）能够强烈抑制肿瘤生长[1]。 |
| Synonyms | ADT 007, ADT007 |
| molecular weight | 449.47 |
| Molecular formula | C26H24FNO5 |
| CAS | 1945941-09-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Jeremy B Foote, et al. A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer. bioRxiv[Preprint]. 2024 Jan 24:2023.05.17.541233. |