Adrenomedullin (AM) (22-52), human acetate Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and an adrenomedullin receptor.
In vitro	Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）能够以剂量依赖性地竞争性抑制Adrenomedullin的结合，并抑制Adrenomedullin在大鼠血管平滑肌细胞中诱导的cAMP积累。此外，Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）（30 nmol）能够选择性且可逆地减少对人际钙调肽基因相关肽（hCGRP）的血管舒张反应，其效果与CGRP拮抗剂类似。
Synonyms	Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）
molecular weight	3636.09
Molecular formula	C161H256N46O50
Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Ziolkowska A, et al. Effects of adrenomedullin and its fragment 22-52 on basal and ACTH-stimulated secretion of cultured rat adrenocortical cells. Int J Mol Med. 2003 May;11(5):613-5. 2. Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42.

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