| Description | Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo. |
| In vitro | Adenosine Dialdehyde (ADOX) 在组织培养中抑制MNB细胞复制，其半最大抑制浓度为1.5 μM，抑制率达50%[1]。 |
| In vivo | Adenosine Dialdehyde （皮下注射；1.5-2.5 mg/kg；通过mini泵（minipump）输注，两个7天周期间隔一周的无药期）在小鼠中将平均寿命提高了80%（对照组，21.3天；AD处理后，38.4天）。同样是Adenosine Dialdehyde （皮下注射；1.5-2.5 mg/kg；通过mini泵输注，持续7天周期），显著延长携带肿瘤小鼠的平均寿命，从溶剂对照组的20.9天延长至AD处理后的35.3天。Adenosine Dialdehyde （皮下注射；2-3 mg/kg；通过mini泵输注，持续7天周期）在小鼠中未表现出任何造血毒性，并能显著抑制小鼠神经母细胞瘤肿瘤的生长，同时几乎不产生全身毒性[2]。 |
| Synonyms | 腺苷二醛, Periodate-oxidized adenosine, Adenosine, periodate oxidized, Adenox, Adenosinedialdehyde |
| molecular weight | 265.23 |
| Molecular formula | C10H11N5O4 |
| CAS | 34240-05-6 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (169.66 mM), Sonication is recommended. |
| References | 1. G V Madhavan, et al. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem. 2. B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48(21):5933-6. |
| Citations | 1. Tang X, Zeng P, Liu K, et al.The PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation.Nature Communications.2024, 15(1): 2813. |