| Description | AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of 5.054 μM, inhibits Aβ aggregation, and exhibits favorable blood-brain barrier permeability. Additionally, it enhances cognitive and spatial memory in a rat model [1]. |
| In vitro | AChE/Aβ-IN-2（化合物33）（5-20 μM；48小时）能够有效地抑制Aβ1-42（10 μM）的聚集[1]。 |
| In vivo | AChE/Aβ-IN-2（化合物33）（10 mg/kg/d；口服；连续7日）有效抑制了Aβ1-42在大鼠体内引发的记忆缺失，并缩减了大鼠在Morris水迷宫测试中的平台区停留时间[1]。 |
| molecular weight | 356.89 |
| Molecular formula | C20H25ClN4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |