| Description | AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM. Additionally, it impedes Aβ aggregation, exhibits favorable blood-brain barrier permeability, offers neuroprotection, and enhances cognitive and spatial memory in rat models [1]. |
| In vitro | AChE/Aβ-IN-1（化合物32）（5-20 μM；48小时）能够抑制Aβ1-42（10 μM）的聚集[1]。 |
| In vivo | AChE/Aβ-IN-1（化合物32）以每天10毫克/千克的剂量通过口服给药7天，有效抑制了Aβ1-42引起的大鼠记忆缺损，并缩短了其在Morris水迷宫平台区的逗留时间[1]。 |
| molecular weight | 401.34 |
| Molecular formula | C20H25BrN4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |