| Description | ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging. |
| Target activity | mGluR5 (human):1.7 nM (Ki) |
| Synonyms | ABP-688, ABP 688 |
| molecular weight | 240.3 |
| Molecular formula | C15H16N2O |
| CAS | 924298-51-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.39 mg/mL (10 mM) |
| References | 1. DeLorenzo C, et al. In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biol Psychiatry. 2015 Feb 1;77(3):266-275. 2. DeLorenzo C, et al. Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [¹¹C]ABP688. Transl Psychiatry. 2015 Dec 8;5:e693. 3. Hintermann S, et al. ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg Med Chem. 2007 Jan 15;15(2):903-14. 4. DuBois JM, et al. Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. Eur J Nucl Med Mol Imaging. 2016 Jan;43(1):152-62. |