| Description | 6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor. |
| Synonyms | 6H05 TFA, 6H05 trifluoroacetate |
| molecular weight | 590.14 |
| Molecular formula | C22H31ClF3N3O4S3 |
| CAS | 2061344-88-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 51 mg/mL (86.42 mM) |
| References | 1. Lu S , Li S , Zhang J . Harnessing Allostery: A Novel Approach to Drug Discovery[J]. Medicinal Research Reviews, 2014, 34(6):1242-1285. 2. Ostrem J M , Peters U , Sos M L , et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions[J]. Nature, 2013, 503(7477):548-551. |