| Description | 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC 50 of 33.4 nM. It can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease [1] [2]. |
| In vitro | 5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC 50 values ranging from 12.6 to 57.5 μM [1]. 5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines [3]. |
| In vivo | 5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) significantly reduces visceral hypersensitivity in irritable bowel syndrome (IBS) rats [2]. |
| molecular weight | 296.17 |
| Molecular formula | C11H14BrN5 |
| CAS | 393129-91-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |