| Description | 5,6-trans-Vitamin D3（5,6-trans-Cholecalciferol） is an isoform of Vitamin D3, which is converted from Vitamin D3 on the skin surface after light exposure. |
| In vitro | 维生素 D 受体（VDR）对 25-羟基倍半萜醇 3、25-羟基-5,6-反式维生素 D3 和 5,6-trans-vitamin D3 的解离常数分别为 22、58 和 560 nM。7-去氢胆固醇、倍半萜醇和卢米斯特醇的解离常数大于 20microM。总之维生素 D3 及其光异构体和预维生素 D3 的光异构体在培养的人角质细胞中具有抗增殖活性。 |
| Synonyms | 5,6-trans-Colecalciferol, 5,6-trans-Cholecalciferol, Cholecalciferol EP Impurity A |
| molecular weight | 384.64 |
| Molecular formula | C27H44O |
| CAS | 22350-41-0 |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 30 mg/mL DMF: 10 mg/mL (26.00 mM), Sonication is recommended. Ethyl Acetate: 20 mg/mL (52.00 mM) DMSO: 1 mg/mL (2.60 mM), Sonication is recommended. |
| References | 1. Chen TC,et al. An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. J Nutr Biochem. 2000 May;11(5):267-72. |