| Description | 4-Isopropylcatechol is a potent depigmenting agent and is of use in the topical therapy of selected patients with hypermelanosis. |
| In vitro | 4-Isopropylcatechol（4-IPC），一种强效、不可逆的皮肤脱色剂，对小鼠恶性黑色素瘤细胞的蛋白质生物合成作用通过考察体外氨基酸（亮氨酸）在细胞液微粒体分数中的掺入而研究。本研究揭示，4-IPC并不抑制小鼠肝脏无细胞系统的蛋白质生物合成，但在含有高水平酪氨酸酶的小鼠黑色素瘤细胞中显著抑制该过程。当添加酪氨酸酶后，在小鼠肝脏无细胞系统中也发现了增强的抑制作用。4-IPC的空气氧化产物并非该抑制作用的原因[1]。 |
| molecular weight | 152.19 |
| Molecular formula | C9H12O2 |
| CAS | 2138-43-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 9 mg/mL (59.14 mM) |
| References | 1. Sugano H , Sugano I , Jimbow K , et al. Tyrosinase mediated inhibition of in vitro leucine incorporation into mouse melanoma by 4 isopropylcatechol[J]. Cancer Research, 1975, 35(11 Pt 1):3126. 2. Bleehen S S . The treatment of hypermelanosis with 4-isopropylcatechol[J]. British Journal of Dermatology, 1975. |