| Description | 3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents. |
| In vitro | All three extracts were found to exhibit antiinflammatory activity with the chloroform extract being the most active. Chemical investigations of petroleum ether and chloroform extracts led to the isolation of beta-sitosterol, ursolic acid, oleanolic acid, 3-Epiursolic acid, 3-epioleanolic acid, and minor triterpenoids of derivatives of ursolic acid and oleanolic acids. Chromatographic purification of the methanol extract yielded two iridoid glucosides, verbenalin and hastatoside, a phenylpropanoid glycoside, verbascoside and beta-sitosterol-D-glucoside. |
| Target activity | Cathepsin L:19.5 μM (Ki), Cathepsin L:6.5 μM (IC50) |
| molecular weight | 456.7 |
| Molecular formula | C30H48O3 |
| CAS | 989-30-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (98.53 mM), Sonication is recommended. |
| References | 1. Antiinflammatory activity and chemical composition of extracts of Verbena officinalis.Phytother Res. 2000 Sep;14(6):463-5. |