| Description | 22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF). Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1]. |
| Synonyms | 22-(4′-Pyridinecarbonyl) jorunnamycin A |
| molecular weight | 598.6 |
| Molecular formula | C32H30N4O8 |
| CAS | 1178895-15-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |