| Description | 21-deacetyldeflazacort is a metabolite of Deflazacort, which is a systemic corticosteroid and a derivative of prednisolone. |
| In vitro | 21-deacetyldeflazacort 在体外研究中，能够从大鼠肾脏、胸腺和肝脏的细胞质受体位点中置换[3H]dexamethasone。 |
| In vivo | 21-deacetyldeflazacort在大鼠中抑制了48小时同源性被动皮肤过敏反应，但对小鼠的主动性全身过敏反应、离体豚鼠气管的Schultz-Dale反应以及大鼠腹膜肥大细胞中compound 48/80引起的组胺释放无显著影响。此外，21-deacetyldeflazacort在大鼠中抑制了逆转皮肤过敏反应以及小鼠的Arthus反应[1]。 |
| molecular weight | 399.48 |
| Molecular formula | C23H29NO5 |
| CAS | 13649-57-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 65 mg/ml (162.71 mM) |
| References | 1. Omote M, et al. Acute effects of deflazacort and its metabolite 21-desacetyl-deflazacort on allergic reactions. Arzneimittelforschung. 1994 Feb;44(2):149-53. 2. Luzzani F, Glässer A. Differential binding in vitro to glucocorticoid receptors of deflazacort and prednisolone. Eur J Pharmacol. 1981 Dec 17;76(4):427-30. doi: 10.1016/0014-2999(81)90115-1. 3. Ifa DR, et al. Determination of 21-hydroxydeflazacort in human plasma by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Application to bioequivalence study. J Mass Spectrom. 2000 Mar;35(3):440-5. 4. Reynolds DL, et al. Quantitative determination of 21-hydroxy-deflazacort in human plasma using gradient semi-microbore liquid chromatography. Biomed Chromatogr. 1994 Sep-Oct;8(5):230-5. |