| Description | 1M6 (1-Methyl-6-nitroisatoic anhydride) is a SHAPE reagent for the detection of RNA chemical structures. |
| Synonyms | 1M-6, 1M 6, 1-Methyl-6-nitroisatoic anhydride |
| molecular weight | 222.15 |
| Molecular formula | C9H6N2O5 |
| CAS | 4693-01-0 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (225.07 mM), Sonication is recommended. |
| References | 1. Eugene YEO, et, al. Methods of identifying protein binding sites on rna. WO2022067036. 2. Busan S, Weeks KM. Accurate detection of chemical modifications in RNA by mutational profiling (MaP) with ShapeMapper 2. RNA. 2018 Feb;24(2):143-148. doi: 10.1261/rna.061945.117. Epub 2017 Nov 7. PubMed PMID: 29114018. 3. Stanford K, Reuter T, Bach SJ, Chui L, Ma A, Conrad CC, Tostes R, McAllister TA. Effect of severe weather events on the shedding of Shiga toxigenic Escherichia coli in slaughter cattle and phenotype of serogroup O157 isolates. FEMS Microbiol Ecol. 2017 Sep 1;93(9). doi: 10.1093/femsec/fix098. PubMed PMID: 28922801. 4. Nwachokor J, Tawfik O, Danley M, Mathur S, House J, Sharma P, Christenson LK, Bansal A. Quantitation of spatial and temporal variability of biomarkers for Barrett's Esophagus. Dis Esophagus. 2017 Sep 1;30(9):1-8. doi: 10.1093/dote/dox023. PubMed PMID: 28859356. |