| Description | 1-vinylpyrene (1-Ethenylpyrene) has antitumor activity and strongly inhibits the formation of skin tumors triggered by DMBA or B[]P in a dose-dependent manner and can be used to prevent tumor formation. |
| In vitro | 1-vinylpyrene（VP）（单剂量；局部应用；初始剂量前5分钟的预处理）通过大约30%抑制了10 nmol DMBA的肿瘤发生；4.4 nmol VP的应用约56%抑制了200 nmol B[a]P的肿瘤发生。A.[2] |
| Synonyms | 1-Ethenylpyrene |
| molecular weight | 228.29 |
| Molecular formula | C18H12 |
| CAS | 17088-21-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble） |
| References | 1. Viaje A, et al. Inhibition of the binding of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene to DNA in mouse skin epidermis by 1-ethynylpyrene. Carcinogenesis. 1990;11(7):1139-1143. 2. Alworth WL, et al. Potent inhibitory effects of suicide inhibitors of P450 isozymes on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene initiated skin tumors. Carcinogenesis. 1991;12(7):1209-1215. |