| Description | Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer. |
| In vitro | 当前可用的抗真菌药物存在局限性，且药物抵抗性菌株迅速出现，这促使我们需要更有效的手段来筛选和开发新型抗真菌药物。研究方法与结果显示，通过评估一系列植物天然产物的抗真菌活性，发现Wighteone (5, 7, 4'-三羟基-6-(γ,γ-二甲基烯丙基)异黄酮) 对酵母菌具有出色的抗生活性（对Saccharomyces cerevisiae的最小抑菌浓度（MIC）为4 microg/ml）。进一步的转录组分析表明，Wighteone处理的S. cerevisiae所展示的模式与常用的抗真菌化合物不同。 |
| Synonyms | Erythrinin B, 6-Isopentenylgenistein |
| molecular weight | 338.35 |
| Molecular formula | C20H18O5 |
| CAS | 51225-30-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL(236.44 mM), Sonication is recommended. |
| References | 1. Pistelli L, et al. Flavonoids from genista ephedroides. J Nat Prod. 1998;61(11):1404-1406. |