| Description | Viscidulin III (Ganhuangenin) is present in Scutellaria baicalensis and acts as an α-glucosidase inhibitor. |
| In vitro | 利用色谱方法分离化合物，光谱方法确定了黄酮类化合物的结构及其在体外模型中的生物活性。共鉴定出九种化合物，分别为baicalein(1)、wogonin(2)、oroxylin A(3)、5, 7, 2', 6'-tetrahydroxyflavone(4)、Viscidulin III(5)、baicalin(6)、wogonoside(7)、oroxylin A-7-O-beta-D-glucuronide(8)及chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside(9)[1]。 |
| Target activity | 3CLpro (SARS CoV-2):1.09 ± 0.14 μM(Kd), HL-60:17.4 μM, 3CLpro (SARS CoV-2):0.84 ± 0.06 μM |
| Synonyms | Ganhuangenin |
| molecular weight | 346.29 |
| Molecular formula | C17H14O8 |
| CAS | 92519-91-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Flavonoids from Scutellaria baicalensis and their bioactivities.Beijing Da Xue Xue Bao. 2009 Oct 18;41(5):578-84. 2. Sonoda M, et al. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. J Ethnopharmacol. 2004;91(1):65-68. 3. Zhu D, et al. Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method. J Pharm Biomed Anal. 2022;209:114538. |