| Description | (-)-Epiafzelechin is a COX inhibitor with antioxidant and anti-inflammatory activity, osteoprotective effects in a mature ovariectomized mouse model, ability to stimulate osteoblast activity and inhibit osteoclast activity. |
| In vitro | (-)-Epiafzelechin 具有显著的抗氧化活性，其 EC50 为 20.9 μM[1]。 |
| molecular weight | 274.27 |
| Molecular formula | C15H14O5 |
| CAS | 24808-04-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (109.38 mM), Sonication is recommended. |
| References | 1. Antioxidant Phenolic Compounds From the Rhizomes of Astilbe Rivularis. Nat Prod Res. 2018 Feb;32(4):453-456. 2. Wong KC,et al. (-)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro. Nutrients. 2017;9(5):530. 3. Min KR, et al. (-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus. Planta Med. 1999;65(5):460-462. |