| Description | Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by activating the Nrf2/HO-1 signaling pathway and blocking mitochondria-dependent apoptotic pathways.Tricetin Inhibits migration and expression of the indicator protease progerin-1 (PS-1) in nasopharyngeal carcinoma through the Akt/GSK-1β pathway.Tricetin inhibits endothelial inflammation induced by oxidized LDL mediated by Egr-1, and protects rat chondrocytes from IL-1β-induced inflammation and apoptosis.Tricetin is an inhibitor of endothelial inflammation induced by oxidized LDL mediated by Egr-1 and protects against IL-1β-induced inflammation and apoptosis. |
| In vitro | Tricetin（20、40和80 μM；4小时）显著提高了由6-OHDA（200 μM）引起的SH-SY5Y细胞的活性，并抑制了线粒体介导的细胞凋亡。[1] 此外，Tricetin（80 μM；1、2和4小时）显著降低了p-JNK和p-p38的表达水平。[1] |
| molecular weight | 302.24 |
| Molecular formula | C15H10O7 |
| CAS | 520-31-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (74.44 mM) |
| References | 1. Ren J, et al. Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. Toxicol Appl Pharmacol. 2019;378:114617. 2. Sun FF, et al. Tricetin Protects Rat Chondrocytes against IL-1β-Induced Inflammation and Apoptosis. Oxid Med Cell Longev. 2019;2019:4695381. 3. Wu S, et al. Identification and Characterization of Two Regiospecific Tricetin UDP-Dependent Glycosyltransferases from Pomegranate (Punica granatum L.). Plants (Basel). 2022;11(6):810. 4. Chung TT, et al. Tricetin suppresses human oral cancer cell migration by reducing matrix metalloproteinase-9 expression through the mitogen-activated protein kinase signaling pathway. Environ Toxicol. 2017;32(11):2392-2399. |