| Description | Transglutaminase (TG) is a thiolase that induces intermolecular cross-linking of proteins, by catalysing the formation of isopeptide bonds between the γ-carboxamide group of glutamine residues and the primary ε-amine group of other compounds. The enzyme plays a role in a variety of physiological processes including coagulation, antimicrobial immune responses and photosynthesis. |
| In vitro | Transglutaminase的活性可通过Co 2+、Ba 2+ 和 K+ 增强[1]。而微生物源Transglutaminase受到Zn 2+、Cu 2+、Hg 2+ 以及Pb 2+ 离子的抑制，这些离子与活性中心的半胱氨酸的硫醇基团结合[1]。 |
| Synonyms | TG |
| molecular weight | N/A |
| CAS | 80146-85-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kieliszek M, et al. Microbial transglutaminase and its application in the food industry. A review. Folia Microbiol (Praha). 2014 May;59(3):241-50. 2. Tripathy D,et al. Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1-42-mediated toxicity. Neurobiol Dis. 2020 Jul;140:104849. |