| Description | Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells. |
| In vitro | Toddaculin在U-937细胞中表现出作为细胞分化剂和凋亡诱导剂的双重效应，暗示它可能作为开发新型抗白血病药物的药理原型[1]。 |
| molecular weight | 274.31 |
| Molecular formula | C16H18O4 |
| CAS | 4335-12-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (200.51 mM) |
| References | 1. Vázquez, Riveiro, M. E , et al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. 2. Kumagai M , Watanabe A , Yoshida I , et al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages[J]. Biological and Pharmaceutical Bulletin, 2018, 41(1):132-137. |